Premature ovarian failure

What is premature ovarian failure?

Premature ovarian failure (POF), also known as primary ovarian insufficiency, is when a woman's ovaries stop functioning normally before age 40. This results in absent or irregular periods and reduced fertility.

Some key points about POF:

• It affects 1% of women under age 40.


• The cause is often unknown, but can include genetic factors, autoimmune diseases, chemotherapy treatment, or infections.


• Women with POF have low estrogen levels and high follicle-stimulating hormone (FSH) levels.


• Symptoms besides absent/irregular periods may include hot flashes, vaginal dryness, mood changes, and trouble conceiving naturally.


• There is no cure, but hormone therapy with estrogen/progestin pills may help relieve symptoms. In vitro fertilization can aid conception.


• Women with POF have an increased risk for osteoporosis and heart disease due to estrogen deficiency.

If you are under 40 and have missed periods for a few months, see your doctor to get tested. Blood tests for FSH and estradiol can help confirm POF. There are options for symptom relief and assisted conception at clinics like Vitality Health Center. Their compassionate physicians create customized hormone therapy to target POF symptoms, protect bone/heart health, and explore paths to pregnancy.

While upsetting, POF is manageable with the right treatment. Reach out to your doctor and support groups to learn coping tips. With a proactive approach, you can still live a healthy, fulfilling life.